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Invitrogen Ki-67 Polyclonal Antibody 500 μL | Buy Online | Invitrogen™ | Fisher Scientific

Invitrogen Ki-67 Polyclonal Antibody 500 μL | Buy Online | Invitrogen™ | Fisher Scientific

Original price was: $334.62.Current price is: $204.30.

SKU: 01950117 Category: Tag:

Description

Rabbit Polyclonal Antibody

Recommended positive controls: Tonsil or Breast carcinoma. Staining of formalin/paraffin tissues requires boiling tissue sections in 10 mM citrate buffer, pH6.0, for 10-20 minutes, followed by coolong at room temperature for 20 minutes.

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.

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